Régis Brion Selected Research

Ligands

10/2018	The Intrinsic and Extrinsic Implications of RANKL/RANK Signaling in Osteosarcoma: From Tumor Initiation to Lung Metastases.
4/2012	Induction of osteogenesis in mesenchymal stem cells by activated monocytes/macrophages depends on oncostatin M signaling.
10/2011	Formulated siRNAs targeting Rankl prevent osteolysis and enhance chemotherapeutic response in osteosarcoma models.

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Régis Brion Research Topics

Disease

11	Osteosarcoma (Osteogenic Sarcoma) 01/2022 - 12/2010
11	Neoplasms (Cancer) 01/2022 - 12/2010
5	Neoplasm Metastasis (Metastasis) 12/2021 - 12/2010
4	Osteolysis 06/2015 - 10/2011
3	Inflammation (Inflammations) 01/2021 - 09/2005
3	Bone Resorption 11/2014 - 04/2012
2	Ewing Sarcoma (Sarcoma, Ewing) 11/2020 - 04/2013
2	Rheumatoid Arthritis 07/2017 - 01/2014
2	Infections 01/2017 - 04/2012
2	Breast Neoplasms (Breast Cancer) 08/2015 - 12/2005
1	Tendinopathy (Tendonitis) 01/2021
1	Experimental Arthritis 07/2017
1	Arthritis (Polyarthritis) 07/2017
1	Foreign Bodies (Foreign Body) 01/2017
1	Vascular Calcification 01/2014
1	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2014
1	Osteitis 04/2012
1	Osteoporosis 01/2012
1	Starvation 12/2005
1	Adenocarcinoma 12/2005
1	Autoimmune Diseases (Autoimmune Disease) 09/2005

Drug/Important Bio-Agent (IBA)

3	LigandsIBA 10/2018 - 10/2011
3	CytokinesIBA 07/2017 - 01/2014
2	Biological ProductsIBA 05/2021 - 12/2005
2	OsteoprotegerinIBA 10/2018 - 01/2014
2	Zoledronic Acid (Zometa)FDA Link 11/2014 - 12/2010
2	Heme Oxygenase-1IBA 12/2005 - 09/2005
2	EnzymesIBA 12/2005 - 09/2005
2	Heme (Haem)IBA 12/2005 - 09/2005
1	SialomucinsIBA 01/2022
1	Methotrexate (Mexate)FDA LinkGeneric 01/2022
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2022
1	Lim KinasesIBA 12/2021
1	ICG 001IBA 05/2021
1	Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)IBA 05/2021
1	CateninsIBA 05/2021
1	Ubiquitin-Specific ProteasesIBA 01/2021
1	ApatitesIBA 01/2021
1	Proteins (Proteins, Gene)FDA Link 01/2021
1	RNA (Ribonucleic Acid)IBA 01/2021
1	Durapatite (Hydroxylapatite)IBA 01/2021
1	calcium phosphateIBA 01/2021
1	GANT 61IBA 11/2020
1	AntigensIBA 07/2017
1	Estrogen ReceptorsIBA 08/2015
1	Conditioned Culture MediaIBA 08/2015
1	Macrophage Colony-Stimulating FactorIBA 07/2015
1	halofuginoneIBA 06/2015
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2014
1	Imatinib Mesylate (Gleevec)FDA Link 01/2014
1	Tyrosine Kinase InhibitorsIBA 01/2014
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 01/2014
1	Connexin 43 (Connexin43)IBA 04/2013
1	EWS-FLI fusion proteinIBA 04/2013
1	Transcription Factors (Transcription Factor)IBA 04/2013
1	Interleukin-6 (Interleukin 6)IBA 04/2012
1	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 04/2012
1	Hydroxymethylglutaryl CoA Reductases (HMG CoA Reductase)IBA 02/2012
1	apomine (SR 45023A)IBA 02/2012
1	Lovastatin (Mevacor)FDA LinkGeneric 02/2012
1	Proteoglycans (Proteoglycan)IBA 01/2012
1	Heparin (Liquaemin)FDA LinkGeneric 01/2012
1	Liposomes (Liposome)IBA 10/2011
1	Small Interfering RNA (siRNA)IBA 10/2011
1	Ifosfamide FDA LinkGeneric 10/2011
1	Drug CombinationsIBA 12/2010
1	Pharmaceutical PreparationsIBA 12/2010
1	Everolimus FDA Link 12/2010
1	Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA 12/2005
1	Methylnitrosourea (N-Methyl-N-nitrosourea)IBA 12/2005

Therapy/Procedure

4	Drug Therapy (Chemotherapy) 01/2022 - 12/2010
3	Therapeutics 08/2015 - 02/2012
2	Injections 07/2017 - 10/2011
1	Arthroplasty 01/2017
1	Oral Administration 01/2014
1	Transplantation 09/2005